229940121650 immune-checkpoint protein inhibitors Drugs 0.000 claims description 173.239000012274 immune-checkpoint protein inhibitor Substances 0.000 claims description 173.238000002360 preparation method Methods 0.000 claims description 197.108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 791.230000001394 metastastic Effects 0.000 claims abstract description 24.206010061289 Metastatic neoplasm Diseases 0.000 claims abstract description 24.239000007787 solid Substances 0.000 claims abstract description 39.
230000002489 hematologic Effects 0.000 claims abstract description 46.238000002560 therapeutic procedure Methods 0.000 claims abstract description 73.206010052015 Cytokine release syndrome Diseases 0.000 claims abstract description 123.238000009169 immunotherapy Methods 0.000 claims abstract description 176.239000000203 mixture Substances 0.000 claims abstract description 332.Publication of WO2019077062A1 publication Critical patent/WO2019077062A1/en Links Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.) Filing date Publication date Priority to US201762573751P priority Critical Priority to US62/573,751 priority Application filed by Vivia Biotech, S.L. Priority date (The priority date is an assumption and is not a legal conclusion. Inventor Daniel PRIMO RAMOS Juan Antonio BALLESTEROS NOBELL Teresa Ann BENNETT Julián GORROCHATEGUI GUILLÉN Joaquín Martínez López Original Assignee Vivia Biotech, S.L. Google Patents WO2019077062A1 - Bite-activated car-t cells